Idiopathic Nephrotic Syndrome

Context : In children, idiopathic nephrotic syndrome (INS) is a condition with high morbidity, although the incidence and risk of relapse have not been thoroughly studied.

Objective: To calculate the overall pooled weighted incidence of INS in children and the risk of relapse.

Sources of information: Medline and Embase are two databases that can help you find information (until December 2020).

Selection for study Incidence (per 100 000 children) in all studies.

Results: A total of 73 studies were included in the analysis after screening (27 incidence, 54 relapse). The incidence was 2.92 (95 percent PI: 0.00–6.51) per 100 000 children per year, according to the overall pooled weighted estimate and accompanying prediction interval (PI). In non-Western countries, the incidence was higher (P.001). White children had a reduced incidence, but this was not statistically significant.


Conclusion: With ethnic heterogeneity, INS has a low incidence but a significant chance of relapse. Despite the fact that corticosteroids have lowered the likelihood of relapse, it remains unacceptably high, highlighting the need for other treatment modalities.

  • Nephrotic syndrome in childhood

  • Recurrence of idiopathic nephrotic syndrome after renal transplantation

  • Idiopathic nephrotic syndrome in children: clinical aspects

  • Idiopathic nephrotic syndrome in children


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